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Lung Cancer

Lung Cancer: Medical Information


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Prevention

Smoking Avoidance
Smoking Cessation
Beta Carotene
Radon Exposure
Vitamin E/Tocopherol


Smoking Avoidance

Based on solid evidence, cigarette smoking causes lung cancer and therefore, smoking avoidance would result in decreased mortality from primary lung cancers.

Description of the Evidence

  • Study Design: Evidence obtained from a randomized controlled trial.
  • Internal Validity: Good.
  • Consistency: Good.
  • Magnitude of Effects on Health Outcomes: Decreased risk, large magnitude.
  • External Validity: Good.
Smoking Cessation

Based on solid evidence, long-term sustained smoking cessation results in decreased incidence of lung cancer and of second primary lung tumors.

Description of the Evidence

  • Study Design: Evidence obtained from case-control and cohort studies.
  • Internal Validity: Good.
  • Consistency: Good.
  • Magnitude of Effects on Health Outcomes: Decreased risk, moderate magnitude.
  • External Validity: Good.
Beta Carotene

Based on solid evidence, high-intensity smokers who take pharmacological doses of beta carotene have an increased lung cancer incidence and mortality that is associated with taking the supplement.

Description of the Evidence

  • Study Design: Evidence obtained from randomized controlled trials.
  • Internal Validity: Good.
  • Consistency: Good.
  • Magnitude of Effects on Health Outcomes: Increased risk, small magnitude.
  • External Validity: Good.
Radon Exposure

Based on solid evidence, exposure to radon increases lung cancer incidence and mortality.

Description of the Evidence

  • Study Design: Evidence obtained from case-control and cohort studies.
  • Internal Validity: Fair.
  • Consistency: Good.
  • Magnitude of Effects on Health Outcomes: Increased risk that follows a dose-response gradient, with small increases in risk for levels experienced in most at-risk homes.
  • External Validity: Fair.
Vitamin E/Tocopherol

Based on solid evidence, taking vitamin E supplements does not affect the risk of lung cancer.

Description of the Evidence

  • Study Design: Evidence obtained from 4 randomized controlled trials.
  • Internal Validity: Good.
  • Consistency: Fair.
  • Magnitude of Effects on Health Outcomes: Strong evidence of no association.
  • External Validity: Good.

 Source:  National Cancer Institute


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